3-hydroxyhexanoylcarnitine (1) to 3-hydroxyhexanoate

Numerator Metabolite

Structure of 3-hydroxyhexanoylcarnitine (1)
Metabolite Accession: GCST90200228
Name: 3-hydroxyhexanoylcarnitine (1)
Hmdb Id: HMDB0013131
Super Pathway: NA
Sub Pathway: NA
Inchikey: VYEONLJQPYRKAN

Denominator Metabolite

Structure of 3-hydroxyhexanoate
Metabolite Accession: GCST90200012
Name: 3-hydroxyhexanoate
Hmdb Id: HMDB0061652,HMDB0010718
Super Pathway: NA
Sub Pathway: NA
Inchikey: HPMGFDVTYHWBAG

Associated Genomic Regions

Region: rs7538652

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.124
Position:
151920040
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
9.165
Reference Allele:
G
-log10(P):
-44.454
MAF:
0.315
Beta (Num):
0.050
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.074
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

The ratio reflects the conversion between 3-hydroxyhexanoylcarnitine and 3-hydroxyhexanoate, a process influenced by mitochondrial fatty acid metabolism where THEM4 plays a role.1[1], 2[2], 4[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered fatty acid metabolism due to THEM4 dysfunction could lead to chronic low-grade inflammation in the colon, a factor in diverticular disease, although a direct causal link is not established.5[1], 6[2]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data