2,6-dihydroxybenzoic acid to 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)

Numerator Metabolite

Structure of 2,6-dihydroxybenzoic acid
Metabolite Accession: GCST90200229
Name: 2,6-dihydroxybenzoic acid
Hmdb Id: HMDB0013676
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKEUNCKRJATALU

Denominator Metabolite

Structure of 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Metabolite Accession: GCST90199712
Name: 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (cmpf)
Hmdb Id: HMDB0061112
Super Pathway: NA
Sub Pathway: NA
Inchikey: WMCQWXZMVIETAO

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.192
Position:
25802083
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-9.459
Reference Allele:
T
-log10(P):
-47.221
MAF:
0.444
Beta (Num):
-0.090
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.102
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Salicylate metabolism, xenobiotic degradation.4[1], 5[2]

Denominator Metabolite Explanation:

Furanoid fatty acid metabolism, uremic toxin.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio likely reflects altered renal clearance, as a dysfunctional SLC17A4 may affect transport of both organic anions, CMPF and 2,6-dihydroxybenzoic acid.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

A variant in the SLC17A4 gene, a known urate transporter, alters its function, directly impacting serum uric acid and creatinine levels.1[1], 9[2] This renal dysfunction can secondarily affect hematological parameters, a known complication of chronic kidney disease.10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data