2,6-dihydroxybenzoic acid to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Structure of 2,6-dihydroxybenzoic acid
Metabolite Accession: GCST90200229
Name: 2,6-dihydroxybenzoic acid
Hmdb Id: HMDB0013676
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKEUNCKRJATALU

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs59569607;rs1937130

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.183
Position:
25787554
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-8.937
Reference Allele:
T
-log10(P):
-42.359
MAF:
0.428
Beta (Num):
-0.094
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.089
SE (Den):
0.014
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Salicylate metabolism4[1], 5[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism6[1]

Ratio Explanation:

The ratio may reflect altered transport of urate and steroid sulfates by SLC17A4, but a direct relationship between the two metabolites is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely impacts uric acid levels and steroid hormone transport, influencing phenotypes related to red blood cell indices and hemoglobin.7[1], 8[2], 6[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data