2,6-dihydroxybenzoic acid to 2-aminooctanoate

Numerator Metabolite

Structure of 2,6-dihydroxybenzoic acid
Metabolite Accession: GCST90200229
Name: 2,6-dihydroxybenzoic acid
Hmdb Id: HMDB0013676
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKEUNCKRJATALU

Denominator Metabolite

Structure of 2-aminooctanoate
Metabolite Accession: GCST90199937
Name: 2-aminooctanoate
Hmdb Id: HMDB0000991
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKVBCGQVQXPRLD

Associated Genomic Regions

Region: rs1165195

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.200
Position:
25815080
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-9.801
Reference Allele:
G
-log10(P):
-50.549
MAF:
0.444
Beta (Num):
-0.090
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.110
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Salicylic acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Amino acid metabolism, Fatty acid metabolism.5[1], 6[2]

Ratio Explanation:

The SLC17A4 transporter may influence the levels of 2,6-dihydroxybenzoic acid (a salicylate metabolite) and 2-aminooctanoate, impacting their relative concentrations in circulation.7[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 transporter function likely modifies urate excretion, directly affecting serum uric acid levels and associated phenotypes like MCHC and MCH.8[1], 9[2], 10[3] A link to hematological phenotypes could also be mediated via thyroid hormone transport.11[4], 12[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data