2,6-dihydroxybenzoic acid to caffeic acid sulfate

Numerator Metabolite

Structure of 2,6-dihydroxybenzoic acid
Metabolite Accession: GCST90200229
Name: 2,6-dihydroxybenzoic acid
Hmdb Id: HMDB0013676
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKEUNCKRJATALU

Denominator Metabolite

Structure of caffeic acid sulfate
Metabolite Accession: GCST90200093
Name: caffeic acid sulfate
Hmdb Id: HMDB0041708
Super Pathway: NA
Sub Pathway: NA
Inchikey: SNVAIAITQIIEMQ

Associated Genomic Regions

Region: rs1165196

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.171
Position:
25813150
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-8.408
Reference Allele:
A
-log10(P):
-37.720
MAF:
0.444
Beta (Num):
-0.090
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.080
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Salicylic acid metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Caffeic acid sulfation5[1], 6[2], 7[3]

Ratio Explanation:

The ratio may reflect altered transport of organic anions by SLC17A4, potentially influencing the balance of these two dietary-derived phenolic acids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely affects urate transport, leading to changes in MCHC, MCH, and other hematological and renal phenotypes.1[1], 8[2], 9[3] This is supported by the association with uric acid levels.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data