2,6-dihydroxybenzoic acid to hydroxy-cmpf*

Numerator Metabolite

Structure of 2,6-dihydroxybenzoic acid
Metabolite Accession: GCST90200229
Name: 2,6-dihydroxybenzoic acid
Hmdb Id: HMDB0013676
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKEUNCKRJATALU

Denominator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.200
Position:
25802083
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-9.698
Reference Allele:
T
-log10(P):
-49.533
MAF:
0.444
Beta (Num):
-0.090
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.110
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Salicylic acid metabolism5[1]

Denominator Metabolite Explanation:

Furan fatty acid metabolism6[1], 7[2]

Ratio Explanation:

The ratio may reflect altered transport of these unrelated metabolites by SLC17A4, though direct transport of either by SLC17A4 is not established.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

A missense variant in the organic anion transporter SLC17A4 is associated with this ratio and multiple hematological and metabolic phenotypes. The phenotypes, including serum creatinine and uric acid, are consistent with the known role of SLC17A4 and related transporters in renal and intestinal substance transport.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data