2,6-dihydroxybenzoic acid to vanillic acid glycine

Numerator Metabolite

Structure of 2,6-dihydroxybenzoic acid
Metabolite Accession: GCST90200229
Name: 2,6-dihydroxybenzoic acid
Hmdb Id: HMDB0013676
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKEUNCKRJATALU

Denominator Metabolite

Structure of vanillic acid glycine
Metabolite Accession: GCST90200253
Name: vanillic acid glycine
Hmdb Id: HMDB0060026
Super Pathway: NA
Sub Pathway: NA
Inchikey: LOODYTDRRBLQNH

Associated Genomic Regions

Region: rs59569607;rs1937130

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.205
Position:
25787554
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-9.948
Reference Allele:
T
-log10(P):
-52.014
MAF:
0.428
Beta (Num):
-0.094
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.111
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Salicylic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Vanillic acid metabolism, Glycine conjugation pathway.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, potentially influencing the balance of these two organic anions, one exogenous and one endogenous/microbial metabolite.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC17A4 gene, a urate transporter, is linked to uric acid levels and red blood cell indices.1[1], 9[2], 2[3], 10[4] Altered SLC17A4 function could impact urate homeostasis, which may indirectly affect hematopoiesis or correlate with red blood cell parameters through pleiotropic effects or shared regulatory pathways.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data