2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to 4-hydroxyphenylacetylglutamine

Numerator Metabolite

Structure of 2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)*
Metabolite Accession: GCST90200233
Name: 2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)*
Hmdb Id: HMDB0240388
Super Pathway: NA
Sub Pathway: NA
Inchikey: XMZBEAXQGSBWLG

Denominator Metabolite

Structure of 4-hydroxyphenylacetylglutamine
Metabolite Accession: GCST90200106
Name: 4-hydroxyphenylacetylglutamine
Hmdb Id: HMDB0006061
Super Pathway: NA
Sub Pathway: NA
Inchikey: CYRKYXZJUIBBJX

Associated Genomic Regions

Region: rs3907532

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.187
Position:
20633785
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-9.186
Reference Allele:
T
-log10(P):
-44.650
MAF:
0.183
Beta (Num):
-0.078
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.109
SE (Den):
0.019
No CNV overlap
rQTL cluster:
29
Reaction Distance:
NA
Closest Genes:
ACSM3 ACSM1 ACSM2B THUMPD1 AC137056.1

LLM Analysis

Numerator Metabolite Explanation:

Methionine, cysteine, SAM, taurine metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Tyrosine metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect the balance between methionine salvage (numerator) and tyrosine metabolism (denominator), potentially influenced by ACSM1 and CRYM's metabolic roles.1[1], 2[2], 3[3], 4[4], 5[5], 6[6], 7[7], 8[8]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Given the lack of a specified phenotype, no definitive causal link can be established between the genes, the metabolic ratio, and a phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data