picolinoylglycine to picolinate

Numerator Metabolite

Structure of picolinoylglycine
Metabolite Accession: GCST90200234
Name: picolinoylglycine
Hmdb Id: HMDB0059766
Super Pathway: NA
Sub Pathway: NA
Inchikey: MNYZGNSHBPLAFN

Denominator Metabolite

Structure of picolinate
Metabolite Accession: GCST90200282
Name: picolinate
Hmdb Id: HMDB0002243
Super Pathway: NA
Sub Pathway: NA
Inchikey: SIOXPEMLGUPBBT

Associated Genomic Regions

Region: rs9922704

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.671
Position:
20560377
SE (Ratio):
0.057
Effect Allele:
C
Z-score (Ratio):
-11.794
Reference Allele:
T
-log10(P):
-72.247
MAF:
0.024
Beta (Num):
-0.136
Novel Locus:
No
SE (Num):
0.050
Beta (Den):
0.535
SE (Den):
0.052
No CNV overlap
rQTL cluster:
28
Reaction Distance:
NA
Closest Genes:
ACSM2B AC137056.1 ACSM3 ACSM2A ACSM1

LLM Analysis

Numerator Metabolite Explanation:

Glycine Conjugation, Xenobiotic Metabolism. 4[1]

Denominator Metabolite Explanation:

Tryptophan Metabolism. 5[1]

Ratio Explanation:

This ratio reflects the glycine conjugation of picolinate; a higher ratio suggests increased formation of picolinoylglycine from picolinate, influenced by ACSM2B activity. 1[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between the ACSM2B-mediated picolinoylglycine/picolinate ratio and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data