picolinoylglycine to kynurenate

Numerator Metabolite

Structure of picolinoylglycine
Metabolite Accession: GCST90200234
Name: picolinoylglycine
Hmdb Id: HMDB0059766
Super Pathway: NA
Sub Pathway: NA
Inchikey: MNYZGNSHBPLAFN

Denominator Metabolite

Structure of kynurenate
Metabolite Accession: GCST90200454
Name: kynurenate
Hmdb Id: HMDB0000715
Super Pathway: NA
Sub Pathway: NA
Inchikey: HCZHHEIFKROPDY

Associated Genomic Regions

Region: rs61825638

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.354
Position:
241713402
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-20.729
Reference Allele:
C
-log10(P):
-218.113
MAF:
0.247
Beta (Num):
-0.018
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.336
SE (Den):
0.017
No CNV overlap
rQTL cluster:
227
Reaction Distance:
NA
Closest Genes:
KMO FH OPN3 CHML WDR64

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism.4[1]

Denominator Metabolite Explanation:

Tryptophan metabolism, Kynurenine pathway.5[1], 6[2], 7[3]

Ratio Explanation:

KMO functional status dictates the balance between picolinoylglycine and kynurenate. Lower KMO activity shunts kynurenine towards kynurenate, potentially affecting picolinoylglycine levels downstream.8[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data