undecenoylcarnitine (c11:1) to dodecanedioate (c12-dc)

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of dodecanedioate (c12-dc)
Metabolite Accession: GCST90199697
Name: dodecanedioate (c12-dc)
Hmdb Id: HMDB0000623
Super Pathway: NA
Sub Pathway: NA
Inchikey: TVIDDXQYHWJXFK

Associated Genomic Regions

Region: rs57025390

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.415
Position:
47412477
SE (Ratio):
0.032
Effect Allele:
G
Z-score (Ratio):
12.818
Reference Allele:
C
-log10(P):
-84.935
MAF:
0.123
Beta (Num):
0.264
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.150
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine transport.6[1]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.3[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects competition between fatty acid beta-oxidation (undecenoylcarnitine) and CYP4A11/4B1-mediated omega-oxidation, which produces dodecanedioate from C12 fatty acids.3[1], 7[2], 6[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data