undecenoylcarnitine (c11:1) to 3-hydroxylaurate

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs2999545

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.258
Position:
151904146
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
12.948
Reference Allele:
T
-log10(P):
-86.622
MAF:
0.389
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.103
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio of undecenoylcarnitine to 3-hydroxylaurate likely reflects activity of fatty acid oxidation pathways, potentially influenced by THEM4's role in hydrolyzing acyl-CoAs.1[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data