undecenoylcarnitine (c11:1) to 3-hydroxysebacate

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Associated Genomic Regions

Region: rs57025390

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.514
Position:
47412477
SE (Ratio):
0.033
Effect Allele:
G
Z-score (Ratio):
15.501
Reference Allele:
C
-log10(P):
-123.105
MAF:
0.123
Beta (Num):
0.264
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.250
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.8[1], 9[2]

Ratio Explanation:

The ratio likely reflects a balance between fatty acid beta-oxidation (numerator) and omega-oxidation (denominator), with genetic links to enzymes in these pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered fatty acid metabolism, indicated by the CYP4B1/THEM4 locus, may influence inflammatory processes in the colon. Chronic low-grade inflammation and changes in fatty acid balance are recognized risk factors for the development and symptoms of diverticular disease.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data