undecenoylcarnitine (c11:1) to 10-undecenoate (11:1n1)

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Associated Genomic Regions

Region: rs73063122

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.150
Position:
21361213
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
7.602
Reference Allele:
A
-log10(P):
-31.168
MAF:
0.166
Beta (Num):
0.087
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.063
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

Region: rs11626972

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.285
Position:
74033594
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
18.907
Reference Allele:
A
-log10(P):
-181.907
MAF:
0.423
Beta (Num):
0.251
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.033
SE (Den):
0.016
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.8[1], 9[2]

Ratio Explanation:

The ratio reflects the balance between a free fatty acid (10-undecenoate) and its carnitine conjugate, likely influenced by hepatic uptake via transporters like SLCO1B1.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLCO1B1 function due to the missense variant likely reduces hepatic uptake of bilirubin and urate, leading to hyperbilirubinemia (high TBil) and gout.12[1], 13[2], 14[3], 15[4] Altered transport of the fatty acid 10-undecenoate could be a parallel effect, explaining the ratio change.10[5], 11[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data