undecenoylcarnitine (c11:1) to sebacate (c10-dc)

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of sebacate (c10-dc)
Metabolite Accession: GCST90199718
Name: sebacate (c10-dc)
Hmdb Id: HMDB0000792
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXMXRPHRNRROMY

Associated Genomic Regions

Region: rs4507958

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.417
Position:
47383041
SE (Ratio):
0.032
Effect Allele:
T
Z-score (Ratio):
13.214
Reference Allele:
A
-log10(P):
-90.123
MAF:
0.126
Beta (Num):
0.255
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.10[1]

Ratio Explanation:

Increased undecenoylcarnitine relative to sebacate could reflect altered fatty acid oxidation, potentially influenced by THEM4 or CYP4B1 activity.1[1], 11[2], 12[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic predisposition through THEM4 may alter fatty acid metabolism, contributing to the inflammatory responses or changes in the colon wall integrity observed in diverticular disease.13[1], 14[2], 15[3], 6[4]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data