undecenoylcarnitine (c11:1) to myristoylcarnitine (c14)

Numerator Metabolite

Metabolite Accession: GCST90200236

Name: undecenoylcarnitine (c11:1)

Hmdb Id: NA

Super Pathway: NA

Sub Pathway: NA

Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199730

Name: myristoylcarnitine (c14)

Hmdb Id: HMDB000506

Super Pathway: NA

Sub Pathway: NA

Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:

Beta (Ratio):

0.279

Position:

74033594

SE (Ratio):

0.016

Effect Allele:

Z-score (Ratio):

17.819

Reference Allele:

-log10(P):

-161.863

MAF:

0.423

Beta (Num):

0.251

Novel Locus:

SE (Num):

0.015

Beta (Den):

-0.028

SE (Den):

0.015

No CNV overlap

rQTL cluster:

Reaction Distance:

Closest Genes:

ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4^[1], 5^[2], 6^[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.7^[1], 8^[2], 9^[3], 10^[4]

Ratio Explanation:

Increased ACOT2 activity likely decreases mitochondrial myristoyl-CoA, reducing myristoylcarnitine (C14) formation, while having less effect on the odd-chain undecenoylcarnitine (C11:1), thus increasing the ratio.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data