undecenoylcarnitine (c11:1) to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs57025390

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.448
Position:
47412477
SE (Ratio):
0.032
Effect Allele:
G
Z-score (Ratio):
14.186
Reference Allele:
C
-log10(P):
-103.511
MAF:
0.123
Beta (Num):
0.264
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.184
SE (Den):
0.022
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Steroidogenesis, specifically corticosteroid biosynthesis.8[1], 9[2]

Ratio Explanation:

This ratio may reflect CYP4B1's metabolic activity, where altered function could shift its preference between fatty acid and steroid substrates.2[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype data is available, so a link between the CYP4B1 variant, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data