undecenoylcarnitine (c11:1) to tridecenedioate (c13:1-dc)*

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199867
Name: tridecenedioate (c13:1-dc)*
Hmdb Id: HMDB02327
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.298
Position:
74033594
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
17.863
Reference Allele:
A
-log10(P):
-162.661
MAF:
0.423
Beta (Num):
0.251
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.047
SE (Den):
0.016
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Dicarboxylic acid metabolism.7[1]

Ratio Explanation:

The ratio reflects the balance between fatty acid beta-oxidation and dicarboxylic acid metabolism, potentially influenced by the hydrolytic activity of ACOT enzymes on acyl-CoAs.1[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a definitive causal link between the ACOT genes, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data