undecenoylcarnitine (c11:1) to octadecanedioylcarnitine (c18-dc)*

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of octadecanedioylcarnitine (c18-dc)*
Metabolite Accession: GCST90199992
Name: octadecanedioylcarnitine (c18-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: ULCCGBCYWCYNIC

Associated Genomic Regions

Region: rs58231493

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.347
Position:
74032122
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
17.561
Reference Allele:
C
-log10(P):
-157.294
MAF:
0.424
Beta (Num):
0.252
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.095
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, dicarboxylic acid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio likely reflects the balance between mitochondrial fatty acid beta-oxidation (numerator) and peroxisomal dicarboxylic acid oxidation (denominator), potentially modulated by ACOT2 and ACOT4 activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was provided, so a link between the ACOT-driven ratio of undecenoylcarnitine to octadecanedioylcarnitine and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data