undecenoylcarnitine (c11:1) to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs57025390

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.461
Position:
47412477
SE (Ratio):
0.031
Effect Allele:
G
Z-score (Ratio):
14.833
Reference Allele:
C
-log10(P):
-112.932
MAF:
0.123
Beta (Num):
0.264
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.197
SE (Den):
0.024
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation; peroxisomal beta-oxidation.7[1], 8[2]

Ratio Explanation:

An altered ratio between undecenoylcarnitine (C11:1) and pimeloylcarnitine (C7-DC) could indicate modified fatty acid omega-oxidation, a pathway involving CYP4 family enzymes.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype data was provided, so a causal link cannot be established. The available data suggests a potential alteration in fatty acid omega-oxidation.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data