undecenoylcarnitine (c11:1) to dodecenedioate (c12:1-dc)*

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of dodecenedioate (c12:1-dc)*
Metabolite Accession: GCST90200159
Name: dodecenedioate (c12:1-dc)*
Hmdb Id: HMDB0000933
Super Pathway: NA
Sub Pathway: NA
Inchikey: MAZWDMBCPDUFDJ

Associated Genomic Regions

Region: rs58231493

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.443
Position:
74032122
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
20.185
Reference Allele:
C
-log10(P):
-206.958
MAF:
0.424
Beta (Num):
0.252
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.192
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

The ratio may reflect competing fatty acid metabolism, with the numerator representing incomplete beta-oxidation and the denominator representing omega-oxidation, a process involving CYP4 enzymes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data