undecenoylcarnitine (c11:1) to tetradecadienoate (14:2)*

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs2999545

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.276
Position:
151904146
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
13.272
Reference Allele:
T
-log10(P):
-90.893
MAF:
0.389
Beta (Num):
0.155
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.121
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Ratio Explanation:

The ratio likely reflects altered mitochondrial fatty acid oxidation, influenced by THEM4's thioesterase activity on acyl-CoA intermediates, affecting both acylcarnitine and dicarboxylate levels.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

THEM4-mediated alteration of fatty acid oxidation may contribute to inflammation or changes in the colonic environment.7[1], 8[2] Imbalanced fatty acids are linked to diverticular disease, a condition involving inflammation of intestinal pouches.9[3], 7[4], 8[5]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data