undecenoylcarnitine (c11:1) to 2-hydroxysebacate

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 2-hydroxysebacate
Metabolite Accession: GCST90200198
Name: 2-hydroxysebacate
Hmdb Id: HMDB0000424
Super Pathway: NA
Sub Pathway: NA
Inchikey: LPIOYESQKJFWPQ

Associated Genomic Regions

Region: rs60705719

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.451
Position:
47382639
SE (Ratio):
0.034
Effect Allele:
C
Z-score (Ratio):
13.121
Reference Allele:
G
-log10(P):
-88.882
MAF:
0.116
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
-0.185
SE (Den):
0.024
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, Dicarboxylic acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

An elevated ratio of undecenoylcarnitine to 2-hydroxysebacate could imply reduced CYP4B1 activity, leading to decreased omega-oxidation (denominator) and accumulation of beta-oxidation intermediates (numerator).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data