undecenoylcarnitine (c11:1) to branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.378
Position:
74033594
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
18.445
Reference Allele:
A
-log10(P):
-173.262
MAF:
0.423
Beta (Num):
0.251
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.127
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance between acylcarnitine formation and acyl-CoA hydrolysis. Increased ACOT activity could decrease C11:1-carnitine by depleting its precursor, C11:1-CoA.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data