undecenoylcarnitine (c11:1) to beta-hydroxyisovalerate

Numerator Metabolite

Metabolite Accession: GCST90200236
Name: undecenoylcarnitine (c11:1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200322
Name: beta-hydroxyisovalerate
Hmdb Id: HMDB0000754
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs10888445

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.262
Position:
151841770
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
12.989
Reference Allele:
T
-log10(P):
-87.158
MAF:
0.395
Beta (Num):
0.150
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.111
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Leucine metabolism/degradation.7[1], 8[2], 9[3]

Ratio Explanation:

A lower ratio of undecenoylcarnitine to beta-hydroxyisovalerate could suggest increased THEM4 activity, promoting fatty acid breakdown over leucine catabolism byproducts.1[1], 4[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data