pregnenetriol disulfate* to pregnenediol disulfate (c21h34o8s2)*

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199840
Name: pregnenediol disulfate (c21h34o8s2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2011425

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.145
Position:
234627608
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-11.877
Reference Allele:
T
-log10(P):
-73.238
MAF:
0.080
Beta (Num):
-0.162
Novel Locus:
Yes ✔️
SE (Num):
0.026
Beta (Den):
-0.016
SE (Den):
0.025
No CNV overlap
rQTL cluster:
136
Reaction Distance:
NA
Closest Genes:
UGT1A10 UGT1A5 UGT1A8 UGT1A6 UGT1A4

Region: rs73076175

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.178
Position:
35989989
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
-18.594
Reference Allele:
A
-log10(P):
-176.015
MAF:
0.143
Beta (Num):
0.037
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.214
SE (Den):
0.019
No CNV overlap
rQTL cluster:
116
Reaction Distance:
NA
Closest Genes:
UGT3A1 UGT3A2 CAPSL LMBRD2 IL7R

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis

Denominator Metabolite Explanation:

Steroidogenesis

Ratio Explanation:

The ratio of pregnenetriol to pregnenediol metabolites reflects steroid biosynthesis activity.8[1] UGT enzymes can glucuronidate precursor steroids, and variants may alter this metabolism.9[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

UGT1A variants decrease enzyme function, impairing both bilirubin and steroid precursor metabolism.3[1], 9[2], 10[3] This leads to elevated total bilirubin and altered steroid hormone levels.

Phenotype Driver:

Gene-centric:UGT1A_locus

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data