pregnenetriol disulfate* to androstenediol (3beta,17beta) disulfate (1)

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (1)
Metabolite Accession: GCST90199842
Name: androstenediol (3beta,17beta) disulfate (1)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.327
Position:
99075038
SE (Ratio):
0.028
Effect Allele:
C
Z-score (Ratio):
11.851
Reference Allele:
T
-log10(P):
-72.933
MAF:
0.035
Beta (Num):
0.012
Novel Locus:
No
SE (Num):
0.039
Beta (Den):
-0.316
SE (Den):
0.038
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Sulfation4[1], 5[2]

Denominator Metabolite Explanation:

Steroidogenesis, Sulfation6[1], 7[2]

Ratio Explanation:

This ratio reflects the balance of two sulfated steroid hormone precursors from the adrenal glands and gonads, potentially influenced by sulfotransferase activity.5[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in GAL3ST4 may alter steroid sulfation, affecting the balance of steroid hormones which are known to modulate inflammatory (CRP), metabolic (BMI), and growth (Height) processes, thus influencing these phenotypes.9[1], 10[2], 11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Metabolite-centric[pregnenetriol disulfate and androstenediol (3beta,17beta) disulfate (1)]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data