pregnenetriol disulfate* to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs12132488

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.179
Position:
47389613
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
10.791
Reference Allele:
C
-log10(P):
-60.833
MAF:
0.128
Beta (Num):
-0.010
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.189
SE (Den):
0.022
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs3732219

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.168
Position:
234627248
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-8.537
Reference Allele:
C
-log10(P):
-38.827
MAF:
0.083
Beta (Num):
-0.153
Novel Locus:
Yes ✔️
SE (Num):
0.025
Beta (Den):
0.015
SE (Den):
0.026
No CNV overlap
rQTL cluster:
136
Reaction Distance:
NA
Closest Genes:
UGT1A10 UGT1A5 UGT1A8 UGT1A6 UGT1A7

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis3[1], 4[2]

Denominator Metabolite Explanation:

Steroid biosynthesis5[1], 6[2]

Ratio Explanation:

The ratio reflects the relative activity of sulfotransferases on different steroid substrates; a lower ratio may indicate increased SULT2A1 activity.1[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with altered sulfation of steroids and bile acids, which can impact bile composition.7[1], 8[2], 9[3] This altered metabolism is a risk factor for cholelithiasis (gallstones), likely due to changes in cholesterol and bile acid solubility.7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data