pregnenetriol disulfate* to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.220
Position:
21343833
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
11.206
Reference Allele:
A
-log10(P):
-65.432
MAF:
0.156
Beta (Num):
0.103
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.117
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Pregnenolone steroid biosynthesis.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.8[1]

Ratio Explanation:

The ratio may reflect altered steroid metabolism or transport by OATP1B1, as SLCO1B1 transports steroid conjugates, potentially affecting the balance between pregnenolone and androgen derivatives.4[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can alter the transport of steroid sulfates, potentially impacting steroid hormone balance.10[1], 9[2] This alteration, along with SLCO1B1's known role in statin transport, may contribute to coronary atherosclerosis risk and affect clinical chemistry markers like bilirubin and lipids.2[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data