pregnenetriol disulfate* to 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Metabolite Accession: GCST90200172
Name: 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Hmdb Id: HMDB0061643
Super Pathway: NA
Sub Pathway: NA
Inchikey: RIJDKRLRDVBUHJ

Associated Genomic Regions

Region: rs112997117

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.388
Position:
101619779
SE (Ratio):
0.043
Effect Allele:
C
Z-score (Ratio):
-8.964
Reference Allele:
T
-log10(P):
-42.610
MAF:
0.059
Beta (Num):
-0.177
Novel Locus:
Yes ✔️
SE (Num):
0.030
Beta (Den):
0.210
SE (Den):
0.032
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
ABCC2 DNMBP CUTC COX15 ENTPD7

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis, specifically pregnenolone metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Furanoid fatty acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio of pregnenetriol disulfate to 3-cmpfp may reflect altered hepatic clearance by the ABCC2 transporter, which handles sulfated steroids and organic anions, although a direct link is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired ABCC2 function due to genetic variation can reduce the transport of bile acids and other conjugated compounds, leading to cholestasis and subsequent increases in liver enzymes like GGT, AST, and ALT, which are markers of liver damage.7[1], 8[2]

Phenotype Driver:

Gene-centric:ABCC2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data