pregnenetriol disulfate* to pregnenetriol sulfate*

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Associated Genomic Regions

Region: rs55672373

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.209
Position:
101594853
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-11.278
Reference Allele:
C
-log10(P):
-66.252
MAF:
0.059
Beta (Num):
-0.177
Novel Locus:
Yes ✔️
SE (Num):
0.030
Beta (Den):
0.031
SE (Den):
0.027
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
ABCC2 DNMBP CUTC COX15 ENTPD7

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Sulfation.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Steroidogenesis, Sulfation.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect altered hepatic transport by ABCC2, which can excrete sulfated steroids, potentially leading to the accumulation of one form over another.4[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced ABCC2 function can impair biliary excretion of various substances, causing hepatocellular stress.10[1], 11[2] This is reflected by the altered steroid ratio and elevated liver damage markers (AST, ALT, GGT), which are observed in conditions like Dubin-Johnson syndrome caused by ABCC2 mutations.11[3], 12[4]

Phenotype Driver:

Gene-centric:ABCC2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data