tetradecadienedioate (c14:2-dc)* to palmitoylcarnitine (c16)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.222
Position:
102075479
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-10.235
Reference Allele:
G
-log10(P):
-54.941
MAF:
0.175
Beta (Num):
-0.169
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.053
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.2[1], 3[2], 4[3]

Ratio Explanation:

The ratio reflects the balance between fatty acid omega-oxidation (numerator) and mitochondrial import of palmitate for beta-oxidation (denominator), indicating altered lipid flux.2[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SCD activity, a key enzyme in lipogenesis, dysregulates the balance of fatty acids.1[1], 6[2] This is reflected in the metabolite ratio, contributing to pro-atherogenic conditions like hypercholesterolemia and coronary atherosclerosis, thus linking lipid synthesis to cardiovascular risk.7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:[SCD]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data