tetradecadienedioate (c14:2-dc)* to adrenate (22:4n6)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.232
Position:
61569830
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
14.744
Reference Allele:
C
-log10(P):
-111.618
MAF:
0.341
Beta (Num):
0.050
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.183
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis1[1], 2[2]

Ratio Explanation:

The ratio of tetradecadienedioate to adrenate may reflect the balance between fatty acid degradation and the synthesis of long-chain polyunsaturated fatty acids by FADS enzymes.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are associated with altered levels of adrenate and other polyunsaturated fatty acids, which influences lipid profiles and is linked to a higher risk for cholelithiasis, type 2 diabetes, and pure hypercholesterolaemia.5[1], 6[2], 7[3], 8[4], 9[5], 10[6], 11[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data