tetradecadienedioate (c14:2-dc)* to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.191
Position:
61569830
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
11.973
Reference Allele:
C
-log10(P):
-74.386
MAF:
0.341
Beta (Num):
0.050
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.142
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation

Denominator Metabolite Explanation:

Omega-3 PUFA biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio reflects FADS enzyme activity; a higher value suggests decreased polyunsaturated fatty acid synthesis relative to alternative fatty acid oxidation pathways.8[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter desaturase activity, which is reflected by the ratio. This dysregulation of fatty acid metabolism increases inflammatory and metabolic risk, elevating the likelihood of cholelithiasis, type 2 diabetes, and cardiovascular disease.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data