tetradecadienedioate (c14:2-dc)* to 10-undecenoate (11:1n1)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Associated Genomic Regions

Region: rs4507958

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.571
Position:
47383041
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
-22.628
Reference Allele:
A
-log10(P):
-259.367
MAF:
0.125
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.466
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.6[1]

Ratio Explanation:

The ratio likely reflects altered fatty acid omega-oxidation (numerator), potentially influenced by CYP4 enzymes, and transport activity by SLCO1B1 affecting both metabolites' disposition.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLCO1B1 missense variant alters transporter function, affecting clearance of bilirubin (TBil), urate (Gout), and other endogenous compounds, leading to observed phenotypes.1[1], 7[2], 2[3], 8[4] The associated CYP4 genes influence fatty acid metabolism, likely impacting triglyceride (TG) levels.9[5], 10[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data