tetradecadienedioate (c14:2-dc)* to stearidonate (18:4n3)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs1535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.171
Position:
61597972
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
9.948
Reference Allele:
A
-log10(P):
-52.009
MAF:
0.345
Beta (Num):
0.053
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

n-3 Polyunsaturated fatty acid metabolism.2[1], 7[2]

Ratio Explanation:

The ratio may reflect FADS2 activity; lower activity decreases the denominator (stearidonate) and can shunt precursors to omega-oxidation, potentially increasing the numerator (tetradecadienedioate).4[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS genes alters polyunsaturated fatty acid metabolism, reflected by the ratio. This dysregulation is a known risk factor for dyslipidemia, cholelithiasis, and type 2 diabetes, which are observed as associated phenotypes, by affecting lipid and glucose homeostasis.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data