tetradecadienedioate (c14:2-dc)* to stearoylcarnitine (c18)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearoylcarnitine (c18)
Metabolite Accession: GCST90199743
Name: stearoylcarnitine (c18)
Hmdb Id: HMDB0000848
Super Pathway: NA
Sub Pathway: NA
Inchikey: FNPHNLNTJNMAEE

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.272
Position:
102075479
SE (Ratio):
0.025
Effect Allele:
A
Z-score (Ratio):
-10.825
Reference Allele:
G
-log10(P):
-61.209
MAF:
0.175
Beta (Num):
-0.169
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.103
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Dicarboxylic acid/Fatty acid omega-oxidation.3[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation/Carnitine shuttle.4[1]

Ratio Explanation:

This ratio likely reflects SCD activity; decreased SCD function can increase the stearoyl-CoA substrate pool for stearoylcarnitine formation and potentially shift metabolism towards omega-oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SCD can alter enzyme activity, impacting the balance of fatty acids as reflected by the ratio, which is associated with dyslipidemia and increased risk for atherosclerosis and coronary artery disease.1[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data