tetradecadienedioate (c14:2-dc)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174565

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.231
Position:
61591636
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
9.734
Reference Allele:
C
-log10(P):
-49.882
MAF:
0.131
Beta (Num):
0.071
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.161
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

PUFA biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

An elevated ratio suggests decreased FADS1/FADS2 activity, leading to lower synthesis of the denominator (DPA) and a potential shift towards alternative fatty acid oxidation pathways.1[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants are strongly associated with circulating PUFA levels, lipid metabolism (cholesterol, triglycerides), and risk for type 2 diabetes and skin cancer.8[1], 9[2], 10[3], 11[4] Altered FADS activity impacts inflammatory pathways and cell membrane composition, providing a link to these metabolic and oncologic phenotypes.12[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data