tetradecadienedioate (c14:2-dc)* to octadecanedioate (c18-dc)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of octadecanedioate (c18-dc)
Metabolite Accession: GCST90199805
Name: octadecanedioate (c18-dc)
Hmdb Id: HMDB0000782
Super Pathway: NA
Sub Pathway: NA
Inchikey: BNJOQKFENDDGSC

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.227
Position:
102075479
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-10.456
Reference Allele:
G
-log10(P):
-57.249
MAF:
0.175
Beta (Num):
-0.169
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.058
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

The ratio of tetradecadienedioate to octadecanedioate may reflect altered fatty acid metabolism.4[1], 5[2] SCD's role in desaturating fatty acyl-CoAs suggests it could influence the balance of different dicarboxylic acids.3[3], 6[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SCD activity is associated with lower triglycerides and protection from hyperlipidemia.2[1] Altered dicarboxylic acid ratios, influenced by SCD, may contribute to the development of coronary atherosclerosis and hypercholesterolemia through effects on overall lipid metabolism and membrane composition.3[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data