tetradecadienedioate (c14:2-dc)* to tetradecanedioate (c14-dc)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.201
Position:
102075479
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-11.622
Reference Allele:
G
-log10(P):
-70.224
MAF:
0.175
Beta (Num):
-0.169
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.032
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Dicarboxylic acid metabolism

Denominator Metabolite Explanation:

Dicarboxylic acid metabolism

Ratio Explanation:

This ratio reflects the activity of desaturase enzymes on C14 dicarboxylic acids, a process potentially influenced by ACOT4's regulation of the dicarboxylyl-CoA substrate pool.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetically-driven changes in ACOT4 expression may alter dicarboxylic acid metabolism, as reflected by the ratio. This dysregulation of fatty acids is linked to cardiovascular phenotypes such as coronary atherosclerosis and hypercholesterolaemia, possibly through downstream effects on complex lipid synthesis or signaling.3[1], 4[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:ACOT4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data