tetradecadienedioate (c14:2-dc)* to hexadecanedioate (c16-dc)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.206
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-11.343
Reference Allele:
G
-log10(P):
-66.999
MAF:
0.175
Beta (Num):
-0.169
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.037
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

The ratio reflects the balance of peroxisomal/mitochondrial dicarboxylic acid metabolism.1[1], 2[2] Altered ACOT2/ACOT4 activity affects the hydrolysis of C14:2 vs. C16 dicarboxylyl-CoAs.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Dysregulation of ACOT2/ACOT4 alters dicarboxylic acid levels (reflected in the ratio), contributing to broader lipid metabolism disorders like hypercholesterolaemia and coronary atherosclerosis.4[1], 5[2]

Phenotype Driver:

Gene-centric:ACOT2/ACOT4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data