tetradecadienedioate (c14:2-dc)* to hexanoylglutamine

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Associated Genomic Regions

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.316
Position:
74033594
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-21.507
Reference Allele:
A
-log10(P):
-234.582
MAF:
0.411
Beta (Num):
-0.310
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.005
SE (Den):
0.016
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation, Dicarboxylic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid conjugation, Acyl-CoA metabolism.6[1]

Ratio Explanation:

The ratio likely reflects ACOT2/4 activity, where higher activity reduces acyl-CoA availability, impacting both omega-oxidation (numerator) and glutamine conjugation (denominator) pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in ACOT2/4 alters acyl-CoA metabolism, reflected in the ratio of dicarboxylic acid to acylglutamine. This metabolic dysregulation is associated with systemic changes in red blood cell indices (Hb, Ht, MCH, MCV, MCHC) and other metabolic markers like creatinine and uric acid.1[1]

Phenotype Driver:

Gene-centric:ACOT2/ACOT4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data