tetradecadienedioate (c14:2-dc)* to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.248
Position:
21343833
SE (Ratio):
0.027
Effect Allele:
C
Z-score (Ratio):
9.054
Reference Allele:
A
-log10(P):
-43.430
MAF:
0.158
Beta (Num):
0.131
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.117
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid dicarboxylate metabolism.7[1]

Denominator Metabolite Explanation:

Androgen and steroid hormone biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

A reduced function SLCO1B1 variant alters the transport of both the dicarboxylic acid and androstenediol sulfate, affecting their circulating levels.4[1], 11[2], 12[3], 7[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters the transport of its substrates, tetradecadienedioate and androstenediol sulfate.4[1], 11[2], 12[3] This is linked to coronary atherosclerosis and affects levels of triglycerides and bilirubin, which are also influenced by SLCO1B1 activity.13[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data