tetradecadienedioate (c14:2-dc)* to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.292
Position:
74033594
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-21.489
Reference Allele:
A
-log10(P):
-234.175
MAF:
0.411
Beta (Num):
-0.310
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.018
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.9[1]

Ratio Explanation:

An increased ratio may indicate elevated ACOT activity, diverting myristoleoyl-CoA from carnitine conjugation (denominator) and potentially shunting fatty acids toward omega-oxidation (numerator).1[1], 8[2], 10[3], 9[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype associations were provided; therefore, a causal link between ACOT-driven changes in this fatty acid ratio and a clinical phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data