tetradecadienedioate (c14:2-dc)* to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs58231493

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.295
Position:
74032122
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
-23.013
Reference Allele:
C
-log10(P):
-268.155
MAF:
0.411
Beta (Num):
-0.310
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.015
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects a balance between omega-oxidation (numerator) and beta-oxidation (denominator), potentially modulated by the carnitine transporter SLC22A5's efficiency.1[1], 2[2], 6[3], 7[4], 4[5], 5[6]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A5 can impair carnitine transport, altering fatty acid metabolism, which is reflected by the ratio.1[1], 2[2], 9[3] This systemic metabolic disruption, particularly impacting energy production, may lead to the associated hematological phenotypes like altered monocyte and white blood cell counts.2[4], 9[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data