tetradecadienedioate (c14:2-dc)* to docosatrienoate (22:3n6)*

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.240
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
11.141
Reference Allele:
C
-log10(P):
-64.710
MAF:
0.341
Beta (Num):
0.050
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.190
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio may reflect the balance between omega-oxidation and long-chain polyunsaturated fatty acid synthesis, with lower FADS activity potentially leading to higher relative levels of tetradecadienedioate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are strongly associated with altered polyunsaturated fatty acid levels, impacting inflammatory and metabolic pathways.1[1], 7[2], 8[3], 9[4], 10[5] This dysregulation likely contributes to the diverse range of associated phenotypes, including inflammatory bowel disease, hypercholesterolemia, and Type 2 diabetes.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data