tetradecadienedioate (c14:2-dc)* to 5-dodecenoylcarnitine (c12:1)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12080585

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.176
Position:
47390015
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-8.163
Reference Allele:
T
-log10(P):
-35.654
MAF:
0.124
Beta (Num):
-0.107
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.068
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.304
Position:
74033594
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-20.973
Reference Allele:
A
-log10(P):
-223.210
MAF:
0.411
Beta (Num):
-0.310
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.007
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.10[1], 11[2], 12[3], 13[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.14[1], 15[2], 16[3]

Ratio Explanation:

An increased ratio may reflect a shift towards omega-oxidation (producing tetradecadienedioate) over beta-oxidation, influenced by ACOT2 activity on acyl-CoA intermediates related to dodecenoylcarnitine.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data