tetradecadienedioate (c14:2-dc)* to arachidonate (20:4n6)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.365
Position:
61569830
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
21.833
Reference Allele:
C
-log10(P):
-241.654
MAF:
0.341
Beta (Num):
0.050
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.315
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio may reflect a shift between fatty acid omega-oxidation and polyunsaturated fatty acid synthesis, where lower FADS1/FADS2 activity decreases arachidonate, potentially increasing substrate for other pathways.7[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants are linked to altered polyunsaturated fatty acid levels, impacting inflammation and lipid metabolism.2[1], 9[2], 10[3], 11[4] This influences susceptibility to inflammatory (asthma, IBD) and metabolic (diabetes, hypercholesterolemia, cholelithiasis) diseases, reflecting altered inflammatory and lipid mediator production.12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data