tetradecadienedioate (c14:2-dc)* to 3-hydroxybutyrate

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Associated Genomic Regions

Region: rs12132488

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.163
Position:
47389613
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-7.599
Reference Allele:
C
-log10(P):
-31.142
MAF:
0.127
Beta (Num):
-0.106
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.058
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.306
Position:
74033594
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-21.106
Reference Allele:
A
-log10(P):
-226.001
MAF:
0.411
Beta (Num):
-0.310
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.004
SE (Den):
0.016
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.

Denominator Metabolite Explanation:

Ketogenesis, Fatty acid beta-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between fatty acid omega-oxidation (numerator) and beta-oxidation/ketogenesis (denominator), processes regulated by CYP4 and ACOT enzymes respectively.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype is provided, so a link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data