tetradecadienedioate (c14:2-dc)* to palmitoleate (16:1n7)

Numerator Metabolite

Metabolite Accession: GCST90200239
Name: tetradecadienedioate (c14:2-dc)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.299
Position:
74033594
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-21.410
Reference Allele:
A
-log10(P):
-232.484
MAF:
0.411
Beta (Num):
-0.310
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.011
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation; Dicarboxylic acid metabolism.2[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis; Monounsaturated fatty acid metabolism.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio reflects the balance between fatty acid omega-oxidation, producing tetradecadienedioate, and the monounsaturated fatty acid pool, including palmitoleate, modulated by ACOT enzymes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No FinnGen or BioBank Japan phenotype data was provided, so no causal link between the ACOT genes, the metabolite ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data